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Literature summary extracted from

  • Geyer, M.; Wittinghofer, A.
    GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding protein (1997), Curr. Opin. Struct. Biol., 7, 786-792.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.5.2 GTPase activating protein GAP for Ras-related proteins, stimulates intrinsic GTPase reaction Homo sapiens
3.6.5.2 GTPase activating protein GAP for Ras-related proteins, stimulates intrinsic GTPase reaction Bos taurus
3.6.5.2 GTPase activating protein GAP for Ras-related proteins, stimulates intrinsic GTPase reaction Rattus sp.
3.6.5.2 guanine nucleotide exchange factor GEF facilitates loading with GTP Homo sapiens
3.6.5.2 guanine nucleotide exchange factor GEF facilitates loading with GTP Bos taurus
3.6.5.2 guanine nucleotide exchange factor GEF facilitates loading with GTP Rattus sp.

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.5.2 Arf1 complexed to GDP, common G domain topology Homo sapiens
3.6.5.2 Arf1, complexed to GDP, common G domain topology Rattus sp.
3.6.5.2 Rac1, active conformation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.5.2 guanine nucleotide dissociation inhibitor GDI
-
 Bos taurus
3.6.5.2 guanine nucleotide dissociation inhibitor GDI down-regulating GTPase activity, inhibition of nucleotide dissociation Homo sapiens
3.6.5.2 guanine nucleotide dissociation inhibitor GDI down-regulating GTPase activity, inhibition of nucleotide dissociation Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.2 GTP + H2O Homo sapiens increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP GDP + phosphate
-
 ir
3.6.5.2 GTP + H2O Bos taurus increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP GDP + phosphate
-
 ir
3.6.5.2 GTP + H2O Rattus sp. increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP GDP + phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.2 Bos taurus
-
-
-
3.6.5.2 Homo sapiens
-
-
-
3.6.5.2 Rattus sp.
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.2 GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP Homo sapiens GDP + phosphate
-
 ir
3.6.5.2 GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP Bos taurus GDP + phosphate
-
 ir
3.6.5.2 GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchange factors that facilitates loading with GTP Rattus sp. GDP + phosphate
-
 ir
3.6.5.2 GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP Homo sapiens GDP + phosphate
-
 ir
3.6.5.2 GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP Bos taurus GDP + phosphate
-
 ir
3.6.5.2 GTP + H2O increased rate of nucleotide dissociation by interaction with guanosine exchanges factors that facilitates loading with GTP Rattus sp. GDP + phosphate
-
 ir

Synonyms

EC Number Synonyms Comment Organism
3.6.5.2 Arf 1
-
 Homo sapiens
3.6.5.2 Arf 1
-
 Rattus sp.
3.6.5.2 Rac1 Rho subfamily Homo sapiens
3.6.5.2 Rac1 Rho subfamily Bos taurus
3.6.5.2 Ran Ras-related, participating in nucleocytoplasmatic transport Homo sapiens
3.6.5.2 RAS
-
 Homo sapiens
3.6.5.2 RAS
-
 Bos taurus
3.6.5.2 RAS
-
 Rattus sp.